Having to move around a lot and scavenge for food will do that to you :)
In the end Joel will get infected and will have to be killed...
I have a feeling Joel is infected from the beginning of the game but takes Ellie under his wing to train her until he is ultimately faced with telling her the truth.
These zombie-equivalents are cool and terrifying, but paleness that turns you into a cabbage head is kind of funny nonetheless.
I dunno, there was a couple of things in U3 they did extremely well to keep under wraps while trailers were airing before release, and I don't think many people would have figured. I'm confident the same is happening here.
Anyone thinks there will be a reference to a future IP like there was in UC? I have a feeling some of them movie posters might offer a hint at a future supernatural type of game (Vamps and werewolves)