Mice Mojo

[claud3]

A male contraceptive pill could be on the horizon, as a new scientific study reveals a compound capable of blocking sperm production in mice which could one day be used by humans.

Scientists from the Dana-Farber Cancer Institute and Baylor College of Medicine have discovered a tiny molecule that yields a quick yet perfectly reversible decrease in sperm count in rodents.

The beacon of gender equality, the compound, known as JQ1, infiltrates male testes cells and temporarily made the mice in the experiment infertile as the dose produced fewer and less mobile sperm. The result is non-hormonal birth control; furthermore the effects of it can be reversed or stopped anytime. "Within one to two months [after discontinuing the drug], there was complete restoration in testicular size, sperm number, sperm motility and –importantly – fertility," Dr. James Bradner, an author on the study told the Huffington Post. “The litter size was normal, and there were no obvious, adverse symptoms in these animals," he added.

Dana Farber researchers originally created the JQ1 as a means to block out cancer causing genes, but the results from the initial testing made them seek advice from contraceptive specialists at Baylor to see if the mice formula could be repeated in men. In the new study, published in the Cell journal, researchers showed how JQ1 effectively penetrated the blood-testis boundary in mice, preventing sperm from maturing.

The conclusion was unexpected because few drugs on the market are capable of penetrating the protective gatekeeper known as the blood-testes barrier that safeguards the testicles from matter floating around in the blood stream.

"These findings suggest that a reversible, oral male contraceptive may be possible" Bradner explained.

It’s "a breakthrough new approach," stating that there has not been a new reversible male contraceptive sine the creation of the condom, William Bremner from the University of Washington in Seattle, told Reuters.

"It's exciting basic science that provides a new approach to think about how a contraceptive for men might be designed," says Bremner. "At the same time, it's a long ways from being in clinical trials in men, let alone being on pharmacy shelves."

A contraceptive pill for women has been around for decades, but an equivalent for men has yet to arrive. Vasectomy is the only option for birth control after condoms.

Numerous research teams have developed hormonal pills that are effective, but they disrupt the hormone balance in men, and drug companies have not yet decided to cash out on this approach, Bremner said.

The US market for female birth control pills amounts to $3.5 billion a year according IMS Health Inc, Condom sales amounted to $430 million last year.

Previous attempts at male contraception focused on using a combination of testosterone and progestin intake to lower the sperm count in men, which would reduce the risk of pregnancy.

In the last decade, the focus in male contraceptive research has seen a shift from hormonal toward non-hormonal agents. Last year, a major trial of hormone-based male contraception was stopped because of bad side effects, including depression.

The author of the study has cautioned that even though the new findings are promising, they are just preliminary. "It will take some years of research," Bradner told the Huffington Post "It's just completely unpredictable. But we're working very hard on this problem."

http://rt.com/news/birth-control-pill-male-901/

This is great, to help the man

[DreDayDetox]

I'll wait till they make a pill that doesn't have a testicular cancer rate. Or men could be smarter and maybe pull out if they don't use the condom?

aim for the face!

[claud3]

We are cave men after all, just put it in and extend the family tree

[keefy]

Most pregnancies are due to the same problem as British trains.

Do not pull out on time

[claud3]

Well it a turn for the better and a ideal situation when needed. Us men need help

Hands help and so does the mouth. Sucky sucky $10

[DreDayDetox]

We are cave men after all, just put it in and extend the family tree

To me that is primitive. I don't want to reproduce offspring and ruin my life or be a shit father.

Vasectomy ftw!

[claud3]

Agrew, but some guys never understand what happens when they produce kids and how hard it is to bring them up and how much it costs

[keefy]

To me that is primitive. I don't want to reproduce offspring and ruin my life or be a shit father.

Vasectomy ftw!

You had one already? before or after having children?

[DreDayDetox]

Haven't had one before, but I am really considering it because I don't want kids.

[*goo]

The male contraceptive pill will be a game changer for men. Currently, only women have the ability to truly control their reproductive system.

Giving men the same 'power' will surely be a positive step. Think of all the fathers that didn't want to be one/wasn't ready but didn't get the choice (the woman made it). Having the option to control reproduction without having surgical enhancements will give men a good bit of balance over reproductive rights.

It's long overdue, especially when women have had theirs for what; 40 years or so?

[claud3]

Agree 100% goo. Man needs a helping hand and i do not mean the quickie in the morning. We are responsible for are own actions and drunken nights might be a thing of the past. But then again some men love the feeling if ejectulation, therefore they will feel and not understand they can have that feel good without a baby being made. Enjoy the pleasure and leave out the misery of an unwanted baby

[DreDayDetox]

To be fair Goo, some men use bullshit excuses at a party to have sex without a condom. Because it "Feels real". There's condoms for that. If you're a guy and you got a chick pregnant and she didn't expect that to happen, then you're an asshole.

[keefy]

Doesn't matter I am on the pill.

That phrase will apply to both sexes in future even though neither is.

[claud3]

Sex has two outcomes, a baby or a great night

[keefy]

Cum or not its still fun trying.

[mickice]

One up the bum and you won't be a mum.

[*goo]

To be fair Goo, some men use bullshit excuses at a party to have sex without a condom. Because it "Feels real". There's condoms for that. If you're a guy and you got a chick pregnant and she didn't expect that to happen, then you're an asshole.

Wasn't apportioning blame, merely stating the field will be levelled in terms of actual control over reproductive rights.

Not saying condoms aren't important, either. They're a precaution for transmission of disease too. Not a wholly effective way to reduce pregnancy (or disease!) though, they can tear; for example.

The male contraceptive pill wouldn't remove the need to use a condom but it would provide a less invasive way for men to avoid unwanted pregnancy (virtually) altogether. Both he and she should continue to use them (condoms) for reasons more than pregnancy.


Obligatory Tapatalk Signature

[DreDayDetox]

Well yeah, the reason I didn't disease is because that would be on everyone's mind, drunk or not. I get what you're saying though, but I'm still skeptical, mainly because it's something you have to ingest.

[claud3]

use common sense and you will be sorted