According to Naughty Dog game director Bruce Straley, vehicles will be making a return in Uncharted 2: Among Thieves.
"Interacting with and being on moving vehicles is a gameplay mechanic that will definitely make an appearance in Uncharted 2," said Straley. "It's one of those hallmarks of the genre, let alone the franchise, but we're not quite ready to reveal in what way just yet."
The original game included vehicles such as jet skis and jeeps, though we’ve yet to see what Uncharted 2 will offer in this department. However, early screenshots have revealed that there will be a level or a section of a level that takes place on a moving train. It will be interesting to see what Naughty Dog will cook up in the sequel.
Stay tuned for more details.