Over the last few weeks, gamers have been confused about the compatibility of Guitar Hero and Rock Band guitars. Until now, it was widespread belief that Guitar Hero guitars would work with both games, while Rock Band guitars were exclusive to the title it was designed for.
For the most part, this is true, however, it seems that the PS3 Guitar Hero guitar is not compatible for Rock Band.
When you are using a Guitar Hero guitar on Rock Band, the game will recognize the guitar as a controller, and prompt you to plug in a guitar to play. On the Xbox 360, the wireless guitar from Legends of Rock will work fine to play Rock Band.
There has been no word yet from Harmonix or Red Octane on the subject, but expect to be updated soon on the subject.